The project leading to this application has received funding from the European Union’s Horizon
2020 research and innovation programme under grant agreement No 667387

Scientific and Management Plan

The key and direct objective of SUPRACHEM LAB is to provide a high research programme with a deep knowledge and expertise on Dynamic Interactive Systems which might provide new insights into the basic features that control in real-time the specific multivalent dynamic recognition toward the natural selection of specific complex structures/functions. Research will be guided by the ambitious scientific goal of creating a new generation of highly functional systems. SUPRACHEM LAB will expose researchers to the process of design, generation, and optimization, application of a variety of systems opening the door to the emerging areas paralleling those of chemistry, biology, health, environmental sciences and biotechnology. The main targets demonstrating the ground-breaking nature of the SUPRACHEM LABresearchproject are:

1. Improve the understanding of the adaptive functional self-organization toward the natural selection of the components by exploring the synergistic influence of internal structural self-assembly based on constitution and of self-evolutive behaviors on the addition of stimuli.
2. Accurate control of functional responses through dynamic platforms developed through tuned incorporation of responsive components into nanostructures, with the extension toward the construction of appropriate micro-scaffolds.
3. Investigation of application avenues towards larger impact of developed bio- and environmental responsive “smart” systems like membranes and delivery systems cell recognition and cell growing devices.

A substantial part of the activities will be performed within research projects. These research projects can be envisaged to generally adopt the following flow plan: 

  • All specific projects will start by identification of the specific targets that will be generally being based on the foreseen final application.
  • Once the targets are identified the specific building blocks and interaction possibilities will be undertaken. This step of system design will consist by the synthesis of active molecules assisted by molecular modelling and physical characterisation in order to increase the probabilities of the system performance.
  • The next stage involves system preparation by using different components involved in multivalent interactions with the selected targets. This stage will be performed by using both in the chemistry and physical methods.
  • Following synthesis/preparation, assaying systems need to be developed to test and screen the systems towards the targets.
  • Upon screening, the best system hits will be used in different biotechnological, medical and environmental applications, ranging from membranes to biosensors to diagnostics.

Though separated tasks, there will be a permanent cross-talk in between the different sub-projects to adjust the achievement of SUPRACHEM LAB goals. To obtain a view as general as possible, different families of Dynamic Interactive Systems will be investigated:

The SuparChem Lab group is split in four different subprojects that will allow the group to cover all different families of Dynamic Interactive Systems:

Subproject 1: Dynamic Interactive Systems for Constitutional Water and Ion Channels
Subproject 2: Constitutional systems for DNA transfection and drug delivery
Subproject 3. Dynameric networks and gels for delivery, cell recognition and cell growing
Subproject 4. Modelling and Theoretical chemistry of constitutional systems