The project leading to this application has received funding from the European Union's Horizon
2020 research and innovation programme under grant agreement No 667387

SupraChem Lab
Laboratory of Supramolecular Chemistry for Adaptive Delivery Systems
ERA Chair initiative

Echipa Suprachem LAB

Horizon 2020 WIDESPREAD 2-2014: ERA Chairs
Project no.667387

The strategic objective of the SupraChem Lab Project is to unlock and foster excellent research in PPIMC IntelCentre by setting up a strong research group in the field of hybrid materials for adaptive self-organized supramolecular structures.
It is an already stated political demand to support the public or private R&I performers in the convergence regions in exploiting their potential to fully contribute to the development of their country/region and to the overall European research effort. Romania joined this policy through the Sectorial Operational Programmes and the National Research Programmes that stipulate measures to increase the R&I capacity of the country, to stimulate the cooperation between RTD institutions and enterprises, and to increase the access of enterprises to research and innovation. However the participation of Romania in the European Research Area is still low due especial to the lack of experience in research management and marketing.
The funding, coming from the EU's research and innovation funding programme, Horizon 2020, has offered the opportunity for excellence institutions from the European converging regions to attract top academics so that they can compete with centres of excellence elsewhere in the European Research Area (ERA). The selected institutions have to award ERA Chairs to outstanding academics who have the capacity to raise standards and attract more high level staff as well as money from other sources, such as EU research funding or regional funds. The SupraChem Lab Proposal project will implement a structural change within in “Petru Poni” Institute of Macromolecular Chemistry - IntelCentre, Iasi, Romania by setting up a competitive research group in the field of supramolecular chemistry.

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  We are proud to announce the first SupraChem Lab articles. Congratulations to our collegues !!!

• Tunable Composition of Dynamic Non-Viral Vectors over the DNA Polyplex Formation and Nucleic Acid Transfection - Lilia Clima, Bogdan Florin Craciun, Gabriela Gavril and Mariana Pinteala, Polymers 2019, 11, 1313
- DOI: 10.3390/polym11081313

• Theoretical Modeling of Long-Time Drug Release from Nitrosalicyl-Imine-Chitosan Hydrogels through Multifractal Logistic Type Laws - Anda-Mihaela Craciun, Mihaela Luminita Barhalescu, Maricel Agop, Lacramioara Ochiuz, Computational and Mathematical Methods in Medicine, Volume 2019, Article ID 4091464, 10 pages
- DOI: 10.1155/2019/4091464

• Duodenoscope - Associated Infections beyond the Elevator Channel: Alternative Causes for Difficult Reprocessing - Gheorghe G. Balan, Irina Rosca, Elena-Laura Ursu, Adrian Fifere,Cristian-Dragos Varganici, Florica Doroftei, Ioana-Andreea Turin-Moleavin, Vasile Sandru, Gabriel Constantinescu, Daniel Timofte, Gabriela Stefanescu, Anca Trifan and Catalin Victor Sfarti, Molecules 2019, 24, 2343 (3.060 )
- DOI: 10.3390/molecules24122343

• Genotype comparison of Candida albicans isolates from different clinical samples - Andra-Cristina Bostanaru, Irina Rosca, Bogdan Minea, Valentin Nastasa, Liliana Foia, Iosif Marincu, Mihai Mares, Ovidiu-Alexandru Mederle, Revista Romana de Medicina de Laborator Vol. 27, Nr. 3, Iulie, 2019
- DOI: 10.2478/rrlm-2019-0027

• Synergistic Effect of Low Molecular Weight Polyethylenimine and Polyethylene Glycol Components in Dynamic Nonviral Vector Structure, Toxicity, and Transfection Effciency - Bogdan Florin Craciun, Gabriela Gavril, Dragos Peptanariu, Laura Elena Ursu, Lilia Clima and Mariana Pinteala, Molecules 2019, 24, 1460
• Synthesis, structure, computational modeling, and biological activity of two novel bimesitylene derivatives, Research on Chemical Intermediates 45(2) (2019) 453–469; - Lucian G. Bahrin, Lilia Clima, Sergiu Shova, Irina Rosca, Corneliu Cojocaru, Dana Bejan, Monica C. Sardaru, Narcisa Marangoci, Vasile Lozan, Alexandru Rotaru
• Novel cyclodextrin-based pH-sensitive supramolecular host-guest assembly for staining acidic cellular organelles, Polymer Chemistry 9 (2018), 968; - Gabriela Pricope, Elena Laura Ursu, Monica Sardaru, Corneliu Cojocaru, Lilia Clima, Narcisa Marangoci, Ramona Danac, Ionel Mangalagiu, Bogdan C. Simionescu,Mariana Pinteala, Alexandru Rotaru
DOI: 10.1039/c7py01668a
• Biopolymer Biosynthesis by Lactic Acid Bacteria Strain in Four Different Culture Media, Rev. Roum. Chim., 2018, 63(7-8), 637-642; - Anca Roxana PETROVICI, Alina NICOLESCU, Mihaela SILION, Irina ROSCA, Diana CIOLACU
• Operational Procedures in the Theory of the Drug Release from Chitosan Hydrogels, Materiale Plastice 55(4):590-594; December 2018; - Anda Mihaela CRACIUN, Georgiana SERBAN, Iulia CRUMPEI, Maricel AGOP, Gabriela CIOCA,
• Bichromophoric pyrazoline derivative with solvent-selective photoluminescence quenching, Journal of Molecular Liquids 278 (2019) 156-163 - A.L. Chibac, Gh. Roman, C. Cojocaru, S. Shova, G. Sacarescu, M. Simionescu, L. Sacarescu,
DOI: 10.1016/j.molliq.2019.01.067
• Chitosan-based magnetic adsorbent for removal of water-soluble anionic dye: Artificial neural network modeling and molecular docking insights, International Journal of Biological Macromolecules 123 (2019) 587-599 - C. Cojocaru, P. Samoila, P. Pascariu,
DOI: 10.1016/j.ijbiomac.2018.11.080
• Cinnamyl-imine-chitosan hydrogels. Morphology control, Acta Chemica Iasi, volumul 26, issue 2, 2018 - Anda M. Craciun,
DOI: 10.2478/achi-2018-0014
• Reusable Biocatalyst by Pepsin Immobilization on Functionalized Magnetite Nanoparticles, Revue Roumaine de Chimie, 2018, 63(7-8), 685-695 - Ioan-Andrei DASCĂLU, Leonard IGNAT, Maurușa-Elena IGNAT, Florica DOROFTEI, Kalim BELHACENE, Renato FROIDEVAUX, Mariana PINTEALĂ
• Nitrosalicyl-imine-chitosan hydrogels based drug delivery systems for long term sustained release in local therapy, Journal of Colloid and Interface Science 536 (2019) 196–207, - Anda Mihaela Craciun, Liliana Mititelu Tartau, Mariana Pinteala, Luminita Marin,
DOI: j.jcis.2018.10.048
• Multiple bio-responsive polymer dispersed liquid crystal composites for sensing applications, Journal of Molecular Liquids 272 (2018) 572–582 - Daniela Ailincai, Daniela Pamfil, Luminita Marin,
DOI: 10.1016/j.molliq.2018.09.125
• Multifunctional magnetic cargo-complexes with radical scavenging properties, Materials Science and Engineering: C, 94, 608-618, 2019 - Daniela Ailincai, Dragos Peptanariu, Mariana Pinteala, Luminita Marin

• Drug delivery systems based on biocompatible imino-chitosan hydrogels for local anticancer therapy; Drug Delivery, 25, 2018, 1080–1090 (I.F.: 3.09) - Daniela Ailincai, Liliana Tartau Mititelu, Luminita Marin
DOI: 10.1080/10717544.2018.1466937
• Hyperpolarised NMR to follow water proton transport through membrane channels via exchange with biomolecules; Faraday Discussions, 2018, DOI:10.2478/rrlm-2018-0023 - Viorel Nastasa, Cristina Stavarache, Anamaria Hanganu, Adina Coroaba, Alina Nicolescu, Calin Deleanu, Aude Sadet and Paul R. Vasos
DOI: 10.1039/C8FD00021B
• Phenotypic and genotypic variations in Candida albicans isolates from Romanian patients; Romanian Journal of Laboratory Medicine 2018, DOI:10.2478/rrlm-2018-0023 - Irina Rosca, Andra-Cristina Bostanaru, Bogdan Minea, Valentin Nastasa, Iulian Gherghel, Carmen-Valentina Panzaru, Mihai Mares, Valentina Ruxandra Moroti-Constantinescu
DOI: 10.2478/rrlm-2018-0023
• Gheorghe G Balan, Irina Rosca, Elena-Laura Ursu, Florica Doroftei, Andra-Cristina Bostanaru, Eugen Hnatiuc, Valentin Nastasa, Vasile Sandru, Gabriela Stefanescu, Anca Trifan, Mihai Mares, Plasma-activated water: a new and effective alternative for duodenoscope reprocessing; Infection and Drug Resistance 2018:11 727–733
DOI: 10.1039/C8FD00046H
• Samuel Murail, Tudor Vasiliu, Andrei Neamtu, Mihail Dumitru Barboiu, Fabio Sterpone and Marc Baaden, Water permeation across artificial I-quartet membrane channels: from structure to disorder; Faraday Discussions, 2018
DOI: 10.1039/C8FD00046H
• Andrei Bejan, Daniela Ailincai, Bogdan C. Simionescu and Luminita Marin, Chitosan Hydrogelation with a Phenothiazine based Aldehyde – a Synthetic Approach toward Highly Luminescent Biomaterials; Polymer Chemistry, 2018, 9, 2359 - 2369
• Manuela Maria Iftime, Luminita Marin*, Chiral betulin-imino-chitosan hydrogels by dynamic covalent sonochemistry: Ultrasonics Sonochemistry (I.F. 4.2)
• G. David, L. Clima, M. Calin, C. A. Constantinescu, M. Balan-Porcarasu, C. M. Uritu, B. C. Simionescu, Squalene/polyethylenimine based non-viral vectors: synthesis and use in systems for sustained gene release; Polymer Chemistry, 2018,
DOI: 10.1039/c7py01720k
• I. P. Merlusca, D. S. Matiut, G. Lisa, M. Silion, L. Gradinaru, S. Oprea, I. M. Popa, Preparation and characterization of chitosan-poly(vinyl alcohol)-neomycin sulfate films, Polym. Bull. (2017) (ISI: 1.43).
DOI: 10.1007/s00289-017-2246-1
• Andrei Bejan, Dragos Peptanariu, Bogdan Chiricuta, Elena Bicu, Dalila Belei; Low molecular weight microfibers with light sensing properties. REVISTA DE MATERIALE PLASTICE, vol. 4, 2017 .
• D. Mihailescu, M. Danu, B. Simionescu, P. Botez, L. Savin, S. A. Ibanescu; Rheological Characterization of Acrylic Bone Cements Used in Total Hip Replacement. Mater. Plast., 54(3) 567 (2017).

• A. Rotaru, G. Pricope, T. Planck, L. Clima, E. L. Ursu, M. Pinteala, J. Davis, M. Barboiu. G-quartet hydrogels for effective cell growth applications. Chemical Communications, accepted 2017 (IF: 6.319).
DOI: 10.1039/C7CC07806D
• G. Pricope, M. Sardaru, E. L. Ursu, C. Cojocaru, L. Clima, N. Marangoci, R. Danac, I. Mangalagiu, B. C. Simionescu, M. Pinteala, A. Rotaru. Novel pH-sensitive Supramolecular host-guest assembly for staining cell acidic organelles. Polymer Chemistry, accepted 2017 (IF: 5.520).
DOI: 10.1039/C7PY01668A
• Tudor Pinteala, Anca Eduard Chiriac, Irina Rosca, Francesca Larese Filon, Mariana Pinteala, Anca Chiriac, Cristian Podoleanu, Simona Stolnicu, Marius Florin Coros, Adina Coroaba, Nail Damage (Severe Onychodystrophy) Induced by Acrylate Glue: Scanning Electron Microscopy and Energy Dispersive X-Ray Investigations, Skin Appendage Disord., 2017, 2, 137-142, IF. 2.366,
DOI: 10.1159/000450791
• Irina Roșca, Anca Roxana Petrovici, Dragoș Peptanariu, Alina Nicolescu, Gianina Dodi, Mihaela Avadanei, Iuliu-Cristian Ivanov, Andra-Cristina Bostanaru, Mihai Mareș, Diana Ciolacu, Biosynthesis of Dextran by Weissella confusa and Their In Vitro Functional Characteristics. Int. J. Biol. Macromol., 2017, IF 3.671,
DOI: 10.1016/j.ijbiomac.2017.10.048
• Maria Celina Alexandrica, Mihaela Silion, Daniel Timpu, Marcel Ionel Popa, A study on the intercalation process of Tramadol hydrochloride in ZnAl - nitrate layered double hydroxides, Rev. Roum. Chim., 2016, 61(8-9), 683-688,
• Anda-Mihaela Olaru, Luminita Marin*, Simona Morariu, Gabriela Pricope, Mariana Pinteala, Liliana Tartau-Mititelu,
Biocompatible chitosan based hydrogels for potential application in local tumour therapy;
DOI: 10.1016/j.carbpol.2017.09.066
• Rodinel Ardeleanu, Andrei I. Dascalu, Andrei Neamtu, Dragos Peptanariu, Cristina M. Uritu, Stelian S. Maier, Alina Nicolescu, Bogdan C. Simionescu, Mihail Barboiu and Mariana Pinteala,
Multivalent polyrotaxane vectors as adaptive cargo complexes for gene therapy; Polymer Chemistry, 2018, 9, 845;
• A. I. Dascalu, R. Ardeleanu, A. Neamtu, S. S. Maier, C. M. Uritu, A. Nicolescu, M. Silion, D. Peptanariu, M. Calin, M. Pinteala,
Transfection-capable polycationic nanovectors which include PEGylated-cyclodextrin structural units: a new synthesis pathway; J. Mater. Chem. B, 2017, 5, 7164—7174( Advance Article)
• Bogdan C. Simionescu , Mioara Drobota , Daniel Timpu , Tudor Vasiliu , Cristina Ana Constantinescu, Daniela Rebleanu, Manuela Calinc, Geta David,
Biopolymers/poly(ε-caprolactone)/polyethylenimine functionalized nanohydroxyapatite hybrid cryogel: Synthesis, characterization and application in gene delivery, Materials Science & Engineering C 81 (2017) 167-176;
DOI: 10.1016/j.msec.2017.07.031
• Luminita Marin, Andrei Bejan, Daniela Ailincai, Dalila Belei, Poly(azomethine-phenothiazine)s with efficient emission in solid state, European Polymer Journal 95 (2017) 127-137;
DOI: DOI: 10.1016/j.eurpolymj.2017.08.006
• A.C. Petrovici, I. Rosca, I. Stoica, M. Silion, A. Nicolescu, G. Dodi, N. Simionescu, C-D. Varganici, I.C. Ivanov, M. Pinteala; Biosynthesis of exopolysaccharides by Weissella confusa in a new culture medium; Romanian Biotechnological Letters , Vol. 23, No. 3, 13637, 2018;

• M. Mares, B. Minea, V. Nastasa, I. Rosca, A-C. Bostanaru, I. Marincu, V. Toma, V.C. Cristea, C. Murariu, M. Pinteala, In vitro activity of echinocandins against 562 clinical yeast isolates from a Romanian multicentre study, Medical Mycology, 2017, 0, 1-10;
DOI: DOI: 10.1093/mmy/myx059
• Optimization of Polyplex Formation between DNA Oligonucleotide and Poly(L-Lysine): Experimental Study and Modeling Approach Tudor Vasiliu, Corneliu Cojocaru, Alexandru Rotaru , Gabriela Pricope, Mariana Pinteala and Lilia Clima Int. J. Mol. Sci. 2017, 18(6), 1291;
DOI: 10.3390/ijms18061291
• Development of biocompatible glycodynameric hydrogels joining two natural motifs by dynamic constitutional chemistry - Luminita Marin, Daniela Ailincai, Simona Morariu, Liliana Tartau-Mititelu; Carbohydrate Polymers 170 (2017) 60-71
DOI: 10.1016/j.carbpol.2017.04.055
• G. Fundueanu, M. Constantin, S. Bucatariu, P. Ascenzi, Poly(N-isopropylacrylamide-co-N-isopropylmethacrylamide) thermoresponsive microgels as self-regulated drug delivery system, Macrom. Chem. Phys., 217, 2525-2533, 2016.
DOI: 10.1002/macp.201600324
• M. Constantin, S. Bucatariu, I. Stoica, G. Fundueanu, Smart nanoparticles based on pullulan-g-poly(N-isopropylacrylamide) for controlled delivery of indomethacin, Int. J. Biol. Macromol. 94, Part A, 698-708, 2017.
DOI: 10.1016/j.ijbiomac.2016.10.064
• M. Constantin, S. Bucatariu, F. Doroftei, G. Fundueanu, Smart composite materials based on chitosan microspheres embedded in thermosensitive hydrogel for controlled delivery of drugs, Carbohyd. Polym. 157, 493-502, 2017.
• G. Fundueanu, M. Constantin, S. Bucatariu, P. Ascenzi , pH/thermo-responsive poly(N-isopropylacrylamide-co-maleic acid) hydrogel with a sensor and an actuator for biomedical applications, Polymer 110, 177-186, 2017.
• Pyridyl-indolizine derivatives as DNA binders and pH-sensitive fluorescent dyes. Narcisa-Laura Marangoci, Lacramioara Popovici, Elena-Laura Ursu, Ramona Danac, Lilia Clima, Corneliu Cojocaru, Adina Coroaba, Andrei Neamtu, Ionel Mangalagiu, Mariana Pinteala, Alexandru Rotaru.
Tetrahedron 72 (2016) 8215-8222
• Solvatochromic analysis and DFT computational study of an azomaleimide derivative - Anton Airinei, Dragos Lucian Isac, Mihaela Homocianu, Corneliu Cojocaru,

Solvatochromic analysis and DFT computational study of an azomaleimide derivative
• E. L. Ursu, F. Doroftei, D. Peptanariu, M. Pinteala, A. Rotaru, DNA-assisted decoration of single-walled carbon nanotubes with gold nanoparticles for applications in surface-enhanced Raman scattering imaging of cells, J. Nanopart. Res. (2017) 19:181;
DOI: 10.1007/s11051-017-3876-9
• Salicyl-imine-chitosan hydrogels: Supramolecular architecturing as acrosslinking method toward multifunctional hydrogelsManuela-Maria Iftime, Simona Morariu, Luminita Marin Carbohydrate Polymers 165 (2017) 39-50
DOI: 10.1016/j.carbpol.2017.02.027
• Dual crosslinked iminoboronate-chitosan hydrogels with strongantifungal activity against Candida planktonic yeasts and biofilms - Daniela Ailincai, Luminita Marin, Simona Morariu, Mihai Mares, Andra-Cristina Bostanaru, Mariana Pinteala, Bogdan C. Simionescu, Mihai Barboiu,
DOI: 10.1016/j.carbpol.2016.07.007
• Synthesis, structural characterization and quantum chemical studies of silicon-containing benzoic acid derivatives - Mirela-Fernanda Zaltariov* , Corneliu Cojocaru, Sergiu Shova, Liviu Sacarescu, Maria Cazacu Journal of Molecular Structure
DOI: 10.1016/j.molstruc.2016.05.038
• PDLC composites based on polyvinyl boric acid matrix - a promising pathway towards biomedical engineering - Daniela Ailincai, Cosmin Farcau, Elena Paslaru & Luminita Marin, Liquid Crystals,
DOI: 10.1080/02678292.2016.1172353
• Structure-Directed Functional Properties of Phenothiazine Brominated Dyes: Morphology and Photophysical and Electrochemical Properties - Andrei Bejan, Sergiu Shova, Mariana-Dana Damaceanu, Bogdan C. Simionescu, and Luminita Marin*, Cryst. Growth Des.
DOI: 10.1021/acs.cgd.6b00212
• Artificial water channels - incipient innovative developments, Mihail Barboiu , Chem. Commun., 2016,52, 5657-5665,
DOI: 10.1039/C6CC01724J
• Artificial water channels - incipient innovative developments, Mihail Barboiu , Chem. Commun., 2016,52, 5657-5665,
DOI: 10.1039/C6CC01724J